ANÁLISE DE CAPTURAS HÍBRIDAS PARA HPV EM MULHERES COM LESÃO INTRAEPITELIAL CERVICAL
DOI:
https://doi.org/10.53843/bms.v9i13.558Keywords:
Uterine Cervical Neoplasms, Intraepithelial Lesion, High Grade Squamous Intraepithelial Lesions, Low Grade Squamous Intraepithelial Lesion, Preventive MedicineAbstract
Introduction: It is known that the presence of HPV is closely related to the development of cervical intraepithelial lesions. In order to identify the viral presence in the organism, the search for DNA-HPV is used through the hybrid capture test. The present study aims to evaluate the findings of hybrid captures and compare them with the results of the anatomopathological examination of women with cervical intraepithelial lesions at a diagnostic pathology medical center. Methods: the search for secondary data was carried out through the analysis of reports of positive hybrid capture for HPV, as well as the anatomopathological examination suggestive of cervical intraepithelial lesion. The variables used were the patient's age, hybrid capture report and anatomopathological examination report. Results: The mean age of the studied patients was 30.14 years, and women with high-grade lesions had a higher mean age. As for the anatomopathological examination, most women had low-grade lesions. High-risk HPV was more prevalent both in women with low-grade and high-grade lesions. The sensitivity of the hybrid capture was 62.2%, specificity 28.9% and negative predictive value 63.2%. Discussion: The results obtained were lower than those in the literature, but they corroborate the current guidelines. Conclusion: The study suggests that hybrid capture be used as an auxiliary method for the diagnosis and follow-up of women with cervical injuries.
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References
Silva IN de CJAG da, Câncer (Brasil) IN de, INCA. Parâmetros Técnicos para o Rastreamento do Câncer do Colo do Útero [Internet]. INCA; 2019 [citado 31 de maio de 2023]. Disponível em: https://ninho.inca.gov.br/jspui/handle/123456789/3757
Gavi report. Vaccine [Internet]. 20 de novembro de 2012 [citado 31 de maio de 2023];30:D1–83. Disponível em: DOI: https://doi.org/10.1016/S0264-410X(12)01435-1
https://www.sciencedirect.com/science/article/pii/S0264410X12014351
Crosbie EJ, Einstein MH, Franceschi S, Kitchener HC. Human papillomavirus and cervical cancer. The Lancet [Internet]. setembro de 2013 [citado 30 de maio de 2023];382(9895):889–99. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S0140673613600227 DOI: https://doi.org/10.1016/S0140-6736(13)60022-7
Sasagawa T, Takagi H, Makinoda S. Immune responses against human papillomavirus (Hpv) infection and evasion of host defense in cervical cancer. Journal of Infection and Chemotherapy [Internet]. 2012 [citado 30 de maio de DOI: https://doi.org/10.1007/s10156-012-0485-5
;18(6):807–15. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S1341321X12702040
Richart RM. Cervical intraepithelial neoplasia. Pathol Annu. 1973;8:301–28.13
Almeida CMC, Souza AN, Bezerra RS, Lima FLO, Izabel TDSS. Principais fatores de risco associados ao desenvolvimento do câncer de colo do útero, com ênfase para o Papilomavírus humano (Hpv): um estudo de revisão. RSD [Internet]. 7 de janeiro de 2021 [citado 30 de maio de 2023];10(1):e19810111634. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/11634 DOI: https://doi.org/10.33448/rsd-v10i1.11634
Koeneman MM, Kruitwagen RF, Nijman HW, Slangen BF, Van Gorp T, Kruse AJ. Natural history of high-grade cervical intraepithelial neoplasia: a review of prognostic biomarkers. Expert Review of Molecular Diagnostics [Internet]. 3 de abril de 2015 [citado 30 de maio de 2023];15(4):527–46. Disponível em: http://www.tandfonline.com/doi/full/10.1586/14737159.2015.1012068 DOI: https://doi.org/10.1586/14737159.2015.1012068
Sankaranarayanan R. Screening for cancer in low- and middle-income countries. Annals of Global Health [Internet]. 13 de dezembro de 2014 [citado 30 de maio de 2023];80(5):412. Disponível em: https://annalsofglobalhealth.org/articles/10.1016/j.aogh.2014.09.014 DOI: https://doi.org/10.1016/j.aogh.2014.09.014
Mustafa RA, Santesso N, Khatib R, Mustafa AA, Wiercioch W, Kehar R, et al. Systematic reviews and meta-analyses of the accuracy of HPV tests, visual inspection with acetic acid, cytology, and colposcopy. International Journal of Gynecology & Obstetrics [Internet]. março de 2016 [citado 30 de maio de 2023];132(3):259–65. Disponível em: DOI: https://doi.org/10.1016/j.ijgo.2015.07.024
http://doi.wiley.com/10.1016/j.ijgo.2015.07.024
Adorno FA, Lousada DCF, Coelho KMPA, França PHC. The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination. Jornal Brasileiro de Patologia e Medicina Laboratorial
[Internet]. 2020 [citado 30 de maio de 2023];56(1). Disponível em: http://www.gnresearch.org/doi/10.5935/1676-2444.2020000614
Depuydt CE, Criel AM, Benoy IH, Arbyn M, Vereecken AJ, Bogers JJ. Changes in type-specific human papillomavirus load predict progression to cervical cancer. J Cell Mol Med [Internet]. dezembro de 2012 [citado 30 de maio DOI: https://doi.org/10.1111/j.1582-4934.2012.01631.x
de 2023];16(12):3096–104. Disponível em: https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01631.x
Saslow D, Solomon D, Lawson HW, Killackey M, Kulasingam SL, Cain J, et al. American cancer society, american society for colposcopy and cervical pathology, and american society for clinical pathology screening guidelines for
the prevention and early detection of cervical cancer. Am J Clin Pathol [Internet]. abril de 2012 [citado 31 de maio de 2023];137(4):516–42. Disponível em: https://academic.oup.com/ajcp/articlelookup/doi/10.1309/AJCPTGD94EVRSJCG
Ndifon CO, Al-Eyd G. Atypical squamous cells of undetermined significance. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 [citado 31 de maio de 2023]. Disponível em: http://www.ncbi.nlm.nih.gov/books/NBK557739/
Arbyn M, Martin-Hirsch P, Buntinx F, Van Ranst M, Paraskevaidis E, Dillner J. Triage of women with equivocal or low-grade cervical cytology results: a metaanalysis of the HPV test positivity rate. Journal of Cellular and Molecular Medicine [Internet]. abril de 2009 [citado 31 de maio de 2023];13(4):648–59. Disponível em: https://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2008.00631.x DOI: https://doi.org/10.1111/j.1582-4934.2008.00631.x
Kulasingam SL, Havrilesky LJ, Ghebre R, Myers ER. Screening for cervical cancer: a modeling study for the us preventive services task force. Journal of Lower Genital Tract Disease [Internet]. abril de 2013 [citado 31 de maio de DOI: https://doi.org/10.1097/LGT.0b013e3182616241
;17(2):193. Disponível em: https://journals.lww.com/jlgtd/Abstract/2013/04000/Screening_for_Cervical_Can
cer__A_Modeling_Study.16.aspx
Zeferino LC, Bastos JB, Vale DBAP do, Zanine RM, Melo YLMF de, Primo WQSP, et al. Guidelines for hpv-dna testing for cervical cancer screening in Brazil. Rev Bras Ginecol Obstet [Internet]. junho de 2018 [citado 31 de maio de 2023];40(06):360–8. Disponível em: http://www.thiemeconnect.de/DOI/DOI?10.1055/s-0038-1657754 DOI: https://doi.org/10.1055/s-0038-1657754
Elfström KM, Smelov V, Johansson ALV, Eklund C, Naucler P, ArnheimDahlström L, et al. Long-term hpv type specific risks for ascus and lsil: a 14-year follow-up of a randomized primary hpv screening trial: long-term hpv type-specific risks for ascus/lsil. Int J Cancer [Internet]. 15 de janeiro de 2015 [citado 31 de maio de 2023];136(2):350–9. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/ijc.28984 DOI: https://doi.org/10.1002/ijc.28984
Noël JC, Simon P. Limitations on the detection rate of high-risk hpv by hybrid capture 2 methodology in high grade intraepithelial (Hsil) or atypical squamous cells-cannot exclude hsil (Asc-h) cytological lesions with proved cin2+. Analytical Cellular Pathology [Internet]. 2 de setembro de 2015 [citado 31 de maio de 2023];2015:e746502. Disponível em: https://www.hindawi.com/journals/acp/2015/746502/ DOI: https://doi.org/10.1155/2015/746502
Stoler MH, Wright TC, Sharma A, Apple R, Gutekunst K, Wright TL. High-risk human papillomavirus testing in women with asc-us cytology. American Journal of Clinical Pathology [Internet]. 1o de março de 2011 [citado 31 de maio de 2023];135(3):468–75. Disponível em: https://academic.oup.com/ajcp/article/135/3/468/1766840 DOI: https://doi.org/10.1309/AJCPZ5JY6FCVNMOT
Sauter JL, Mount SL, St. John TL, Wojewoda CM, Bryant RJ, Leiman G. Testing of integrated human papillomavirus mrna decreases colposcopy referrals: could a change in human papillomavirus detection methodology lead to
more cost-effective patient care? Acta Cytologica [Internet]. 2014 [citado 31 de maio de 2023];58(2):162–6. Disponível em: https://www.karger.com/Article/FullText/358246 DOI: https://doi.org/10.1159/000358246
Zhao C, Li Z, Nayar R, Levi AW, Winkler BA, Moriarty AT, et al. Prior highrisk human papillomavirus testing and papanicolaou test results of 70 invasive cervical carcinomas diagnosed in 2012: results of a retrospective multicenter
study. Archives of Pathology & Laboratory Medicine [Internet]. fevereiro de 2015 [citado 31 de maio de 2023];139(2):184–8. Disponível em: http://www.archivesofpathology.org/doi/abs/10.5858/arpa.2014-0028-OA
Diretrizes brasileiras para o rastreamento do câncer do colo do útero [Internet]. INCA - Instituto Nacional de Câncer. 2018 [citado 31 de maio de 2023]. Disponível em: https://www.inca.gov.br/publicacoes/livros/diretrizes-brasileiraspara-o-rastreamento-do-cancer-do-colo-do-utero
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