Association Between Migraine and Cerebrovascular Disorders:
An Integrative Review
DOI:
https://doi.org/10.53843/bms.v8i11.322Keywords:
Cerebrovascular disorders, Clinical Neurology, MigraineAbstract
Abstract: Introduction: Migraine is prevalent in 18% of the population, being more frequent in women. Migraine carriers develop chronic and disabling symptoms, which reduce work productivity and impair social life. Despite its clinical and epidemiological importance, there are few studies on the relationship between migraine and its influence on cerebrovascular disorders, making it a difficult situation to understand and treat for professionals working in the area. The aim of this review will be to understand the association between migraine and cerebrovascular disorders. Methodology: This is an integrative review, using articles from the PubMed, BVS, Scielo, Cochrane and Scopus databases. Studies carried out with humans and animals in the last 10 years, in Portuguese, English and Spanish, were included. Exclusion parameters were: duplicate articles, escape from the topic, reviews and unavailable works. Kappa coefficient was not calculated. Results: Despite the disagreement on the vascular pathophysiology of migraine, studies converge on the prevalence of Stroke (CVA), Transient Ischemic Attack (TIA) and Transient Global Amnesia (TGT) in patients with migraine, especially in those with aura. Topiramate and calcium blockers had lower risks. Discussion: Prevalence of Ischemic and Hemorrhagic Stroke, AGL and TIA in the migraine population, with a possible relationship between these findings and the presence of the patent foramen ovale (PFO), aura and patient age. There must be care in the drug treatment, avoiding the worsening of symptoms. Conclusion: An association was found between migraine and cerebrovascular disorders, especially in cases with aura and in pathophysiological correlations related to PFO, paradoxical embolisms and coagulation disorders.
Metrics
References
Trabattoni D, Fabbiocchi F, Montorsi P, Galli S, Teruzzi G, Grancini L, et al. Sustained long-term benefit of patent foramen ovale closure on migraine. Catheter Cardiovasc Interv. 2011;77(4):570-4. DOI: https://doi.org/10.1002/ccd.22826
Greenberg DA, Aminoff MJ, Simon RP. Headache and facial pain. Clinical Neurology, 8th ed. New York: The Mcgraw-hill Global Education Holdings; 2012. p. 151-2.
Greenberg DA, Aminoff MJ, Simon RP. Headache and facial pain. Clinical Neurology, 8th ed. New York: The Mcgraw-hill Global Education Holdings; 2012. p. 153-5.
DODICK: Dodick, D. W., Loder, E. W., Manack Adams, A., Buse, D. C., Fanning, K. M., Reed, M. L., & Lipton, R. B. (2016). Assessing barriers to chronic migraine consultation, diagnosis, and treatment: results from the Chronic Migraine Epidemiology and Outcomes (CaMEO) study. Headache: The Journal of Head and Face Pain, 56(5), 821-34. DOI: https://doi.org/10.1111/head.12774
Bigal ME, Fernandes LC, Bordini CA, Speciali JG. Custos hospitalares das cefaléias agudas em uma unidade de emergência pública brasileira. Arquivos de Neuro-Psiquiatria. 2000; 58: 664-70. DOI: https://doi.org/10.1590/S0004-282X2000000400011
Siberstein SD, Lipton RB, Solomon S, Mathew NT. Classification of daily and near-daily headaches: proposed revisions to the IHS criteria. Headache. 1994; 34(1):1-7. DOI: https://doi.org/10.1111/j.1526-4610.1994.hed3401001.x
Agostoni, E. C., & Longoni, M. (2018). Migraine and cerebrovascular disease: still a dangerous connection?. Neurological Sciences, 39(1), 33-7. DOI: https://doi.org/10.1007/s10072-018-3429-8
Muñoz-Collazos, M. (2020). Enfermedad cerebrovascular. Acta neurológica Colombia.[en internet].
Yamamoto, F. I. (2009). Doenças cerebrovasculares. Clinica Média. São Paulo, 407-30.
Mendes KDS, Silveira RCdCP, Galvão CM. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & Contexto - Enfermagem. 2008; 17:758-64. DOI: https://doi.org/10.1590/S0104-07072008000400018
Tobis J. Patent foramen ovale and migraine headaches: the saga continues. Catheter Cardiovasc Interv. 2011;77(4):575-6. DOI: https://doi.org/10.1002/ccd.22990
Domitrz I, Styczynski G, Wilczko J, Gadomska L, Parzuchowska B, Domitrz W, et al. Internal jugular vein valve insufficiency is not increased in migraine: an ultrasound study in migraine patients and control participants. The journal of headache and pain. 2013; 14:78. DOI: https://doi.org/10.1186/1129-2377-14-78
Wallasch TM, Beckmann P, Kropp P. Cerebrovascular reactivity during the Valsalva maneuver in migraine, tension-type headache and medication overuse headache. Funct Neurol. 2011;26(4):223-7.
Gilad R, Boaz M, Dabby R, Finkelstein V, Rapoport A, Lampl Y. Migraine and vascular risk factors in the elderly. Geriatr Gerontol Int. 2014;14(1):220-5. DOI: https://doi.org/10.1111/ggi.12061
Mancia G, Rosei EA, Ambrosioni E, Avino F, Carolei A, Daccò M, et al. Hypertension and migraine comorbidity: prevalence and risk of cerebrovascular events: evidence from a large, multicenter, cross-sectional survey in Italy (MIRACLES study). J Hypertens. 2011;29(2):309-18. DOI: https://doi.org/10.1097/HJH.0b013e3283410404
Yi M, Sherzai AZ, Ani C, Shavlik D, Ghamsary M, Lazar E, et al. Strong Association Between Migraine and Transient Global Amnesia: A National Inpatient Sample Analysis. J Neuropsychiatry Clin Neurosci. 2019;31(1):43-8. DOI: https://doi.org/10.1176/appi.neuropsych.17120353
Hoffman V, Xue F, Ezzy SM, Yusuf A, Green E, Eisele O, et al. Risk of cardiovascular and cerebrovascular events and mortality in patients with migraine receiving prophylactic treatments: An observational cohort study. Cephalalgia. 2019;39(12):1544-59. DOI: https://doi.org/10.1177/0333102419856630
Kumar, P., Kijima, Y., West, B. H., & Tobis, J. M. (2019). The connection between patent foramen ovale and migraine. Neuroimaging Clinics, 29(2), 261-70. DOI: https://doi.org/10.1016/j.nic.2019.01.006
Hildick-Smith, D., & Williams, T. M. (2017). Patent Foramen Ovale and Migraine Headache. Interventional cardiology clinics, 6(4), 539-45. DOI: https://doi.org/10.1016/j.iccl.2017.05.006
Diener HC, Kurth T, Holle D. Practical implications of the migraine cardio- and cerebrovascular association: unmet needs of patients. Cephalalgia. 2015;35(2):140-5. DOI: https://doi.org/10.1177/0333102414554662
Adelborg K, Szépligeti SK, Holland-Bill L, Ehrenstein V, Horváth-Puhó E, Henderson VW, et al. Migraine and risk of cardiovascular diseases: Danish population based matched cohort study. BMJ. 2018;360:k96. DOI: https://doi.org/10.1136/bmj.k96
Peroutka SJ. Migraine: a chronic sympathetic nervous system disorder. Headache. 2004;44(1):53-64. DOI: https://doi.org/10.1111/j.1526-4610.2004.04011.x
Martínez-Sánchez P, Martínez-Martínez M, Fuentes B, Cuesta MV, Cuéllar-Gamboa L, Idrovo-Freire L, et al. Migraine and hypercoagulable states in ischemic stroke. Cephalalgia. 2011;31(16):1609-17. DOI: https://doi.org/10.1177/0333102411427599
Pietrobon D, Moskowitz MA. Pathophysiology of migraine. Annu Rev Physiol. 2013;75: 365-91. DOI: https://doi.org/10.1146/annurev-physiol-030212-183717
Etminan M, Takkouche B, Isorna FC, Samii A. Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies. Bmj. 2005;330(7482):63. DOI: https://doi.org/10.1136/bmj.38302.504063.8F
Mahmoud AN, MenAITs A, Elgendy AY, Qazi A, Barakat AF, Saad M, et al. Migraine and the risk of cardiovascular and cerebrovascular events: a meta-analysis of 16 cohort studies including 1 152 407 subjects. BMJ Open. 2018;8(3):e020498. DOI: https://doi.org/10.1136/bmjopen-2017-020498
McKinley EC, Lay CL, Rosenson RS, Chen L, Chia V, Colantonio LD, et al. Risco de acidente vascular cerebral isquêmico e doença coronariana associada à enxaqueca e medicamentos para enxaqueca entre adultos mais velhos. Journal of Headache and Pain. 2021; 22 (1). DOI: https://doi.org/10.1186/s10194-021-01338-z
Feng Y, He X, Yang Y, Chao D, H. Lazarus L, Xia Y. Pesquisa atual sobre a função do receptor de opióides. Curr Drug Targets. 2012; 13 (2): 230–46. DOI: https://doi.org/10.2174/138945012799201612
Roberto G, Raschi E, Piccinni C, Conti V, Vignatelli L, D'Alessandro R, de Ponti F, Poluzzi E. Eventos cardiovasculares adversos associados a triptanos e ergotaminas para o tratamento da enxaqueca: revisão sistemática de estudos observacionais. Cephalalgia. 2015;35 (2): 118–31 DOI: https://doi.org/10.1177/0333102414550416
Champaloux SW, Tepper NK, Monsour M, Curtis KM, Whiteman MK, Marchbanks PA, et al. Use of combined hormonal contraceptives among women with migraines and risk of ischemic stroke. Am J Obstet Gynecol. 2017;216(5):489.e1-.e7. DOI: https://doi.org/10.1016/j.ajog.2016.12.019
Olesen J, Jorgensen MB. Leao's spreading depression in the hippocampus explains transient global amnesia: A hypothesis [press release]. United Kingdom: Blackwell Publishing1986.
Lauritzen M. Pathophysiology of the migraine aura. The spreading depression theory. Brain. 1994;117 ( Pt 1):199-210. DOI: https://doi.org/10.1093/brain/117.1.199
Stefane T, Napoleão AA, Sousa FAEF, Hortense P. Influência de tratamentos para enxaqueca na qualidade de vida: revisão integrativa de literatura. Revista Brasileira de Enfermagem. 2012;65:353-60. DOI: https://doi.org/10.1590/S0034-71672012000200023
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Ana Vitória Romualdo de França, Tobias Barros Madruga, Vanessa de Oliveira e Silva, Luciana Karla Viana Barroso
This work is licensed under a Creative Commons Attribution 4.0 International License.
User licenses define how readers and the general public can use the article without needing other permissions. The Creative Commons public licenses provide a standard set of terms and conditions that creators and other rights holders can use to share original works of authorship and other material subjects to copyright and certain other rights specified in the public license available at https:// creativecommons.org/licenses/by/4.0/deed.pt_BR. Using the 4.0 International Public License, Brazilian Medical Students (BMS) grants the public permission to use published material under specified terms and conditions agreed to by the journal. By exercising the licensed rights, authors accept and agree to abide by the terms and conditions of the Creative Commons Attribution 4.0 International Public License.
