Alopecia androgênica como agravo da infecção por SARS-CoV-2: Uma revisão integrativa

Thamires da Silva Sampaio Medrado; Marcela Vasconcelos  Montenegro; Rafael Cabral de  Carli; Tatiana Lins Carvalho

doi:10.53843/bms.v5i8.213

Authors

Thamires da Silva Sampaio Medrado Universidade de Pernambuco https://orcid.org/0000-0003-3260-4936
Marcela Vasconcelos Montenegro Universidade de Pernambuco, campus de Santo Amaro https://orcid.org/0000-0001-8939-5026
Rafael Cabral de Carli Universidade de Pernambuco, campus de Santo Amaro https://orcid.org/0000-0003-2581-1611
Tatiana Lins Carvalho Universidade de Pernambuco, campus de Santo Amaro https://orcid.org/0000-0002-5754-037X

DOI:

https://doi.org/10.53843/bms.v5i8.213

Keywords:

Hair, Androgens, Coronavirus Infection

Abstract

Introduction: The coronavirus pandemic highlights severe conditions associated to patients with androgenic alopecia, which is related to hormonal variation through the action of androgens. The present review aims to synthesize the evidence that correlates the role of androgens in androgenic alopecia in face of the coronavirus infection. Methodology: This literature review used the descriptors "Adult", "Alopecia" and "COVID-19" along with the Boolean operator "AND" in the bibliographic databases PubMed, SciELO, LILACS and BVS. The filters used were the languages English, Portuguese and Spanish and available full texts focussed on androgenic alopecia and the action of androgens in the pathophysiology of COVID-19. Results: After reading the selected articles, evidence was found about the implications of alopecia in the body, as well as the role of antiandrogens in the pathophysiology of COVID-19 and androgens in facilitating the passage of the virus into the intracellular environment. Discussion: SARS-CoV-2 infection occurs through the association between the virus's spike proteins and the transmembrane protease serine 2 (TMPRSS2) for its penetration into host cells. In addition, androgen receptors act as transcription promoters for TMPRSS2, making it easier for SARS-CoV-2 to enter the intracellular medium. Variations in the androgen receptor gene are related to its sensitivity and are associated with the development of diseases such as androgenic alopecia, a clinical condition that is being associated with severe COVID-19 prognosis and higher hospitalization rates. Conclusion: From the analyzed articles, it becomes evident not only the scarce number of scientific productions on the topic addressed, but also the association between androgenic alopecia and the worsening of COVID-19, in addition to the promising potential of therapies that use anti-androgenic drugs to treat SARS-CoV-2 infections.

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