Estreptococos do grupo B e partos prematuros: uma revisão narrativa

Autores

DOI:

https://doi.org/10.53843/bms.v8i12.450

Palavras-chave:

Estreptococos do Grupo B, Prematuridade, Antibioticoprofilaxia

Resumo

Introdução: Nascimentos prematuros são aqueles que ocorrem antes das 37 semanas de idade gestacional. Uma condição clínica que permanece problemática para a obstetrícia, principalmente pela alta mortalidade neonatal que causa. Embora a maioria das crianças sobreviva, elas correm o risco de maiores danos ao desenvolvimento neurológico e complicações respiratórias e gastrointestinais. Microrganismos, como Streptococcal agalactiae (Grupo B Streptococcal - GBS), têm sido associados à prematuridade. Esta revisão abrangente tem como objetivo apresentar dados sobre a associação entre GBS e prematuridade.

Métodos: Utilizando as palavras-chave Group B Streptococcal, prematurity e Intrapartum antibiotic therapy, foram pesquisados ​​artigos nas seguintes bases de dados: PubMed, Cochrane database of Systematic Reviews, Cochrane Central Register of Controlled Trials e Lilacs/Scielo. Foram considerados os trabalhos mais relevantes aqueles publicados sobre o tema no período de 1º de janeiro de 1973 a 31 de dezembro de 2021 disponíveis nas bases de dados consultadas.

Resultados: A ruptura prematura das membranas ovulares (RPM) ocorre em 1% a 3% das gestações, sendo uma importante causa de morbimortalidade perinatal e estando associada a 30-40% dos partos prematuros. A infecção causada pelo estreptococo do grupo B, tem sido apontada como importante fator de risco de parto prematuro, principalmente em pacientes com amniorrexe prematura das membranas ovulares.

Discussão: Medidas preventivas de profilaxia para gestantes, como medicação intraparto, para reduzir a transmissão vertical de doenças invasivas por GBS resultaram em diminuição significativa da doença precoce do recém-nascido pelo patógeno. Além disso, a penicilina foi e continua sendo o antimicrobiano de escolha devido ao fato de possuir um espectro microbicida mais estreito que a ampicilina, reduzindo assim a probabilidade de desenvolvimento de resistência bacteriana.

Conclusão: O GBS tem sido associado ao aumento do risco de parto prematuro devido à ruptura prematura da membrana. Além disso, a antibioticoterapia para infecção vaginal por bactérias reduziu o parto prematuro com baixo peso em algumas populações.

Métricas

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Biografia do Autor

Cristia Rosineiri Gonçalves Lopes Corrêa, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora- SUPREMA

Faculdade de Ciências Médicas e da Saúde de Juiz de Fora- SUPREMA, Estudante de Medicina

Vitor de Paula Boechat Soares, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora- SUPREMA

Faculdade de Ciências Médicas e da Saúde de Juiz de Fora- SUPREMA, Estudante de Medicina

Diúle Nunes Sales, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora- SUPREMA

Faculdade de Ciências Médicas e da Saúde de Juiz de Fora- SUPREMA, Estudante de Medicina

Mariana Schmidt Cheaitou, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora- SUPREMA

Faculdade de Ciências Médicas e da Saúde de Juiz de Fora- SUPREMA, Estudante de Medicina

Harleson Lopes de Mesquita, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora- SUPREMA

Faculdade de Ciências Médicas e da Saúde de Juiz de Fora- SUPREMA, PhD, Professor de Microbiologia e Imunologia

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23.10.2023

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Cristia Rosineiri Gonçalves Lopes Corrêa, Vitor de Paula Boechat Soares, Nunes Sales D, Mariana Schmidt Cheaitou, Harleson Lopes de Mesquita. Estreptococos do grupo B e partos prematuros: uma revisão narrativa. BMS [Internet]. 23º de outubro de 2023 [citado 30º de abril de 2024];8(12). Disponível em: https://bms.ifmsabrazil.org/index.php/bms/article/view/450